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Her journey to Springfield began with her work on *The Tracey Ullman Show* in the 1980s. This sketch comedy show served as the launchpad for *The Simpsons*. It was here that she began voicing Marge, along with other characters like Patty and Selma Bouvier (Marge's sisters) and a few minor roles. The rest, as they say, is history. When *The Simpsons* was spun off into its own series, Julie was a core member of the cast. The success of *The Simpsons* is because of the phenomenal voice acting of the cast. What's amazing about Julie's work is her ability to maintain a consistent and recognizable voice for Marge throughout the show's incredible run. Think about it: that same distinctive voice has been gracing our screens for over 30 years! It's truly a testament to her talent and dedication.
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Basically, when breast cancer cells have these receptors, it means they're influenced by those hormones or growth factors. This is a crucial piece of information because it dictates how the cancer might behave and, crucially, how it can be targeted with treatments. For example, if the cancer cells have estrogen receptors, they're likely fueled by estrogen. This means treatments that block estrogen, like hormone therapy, can be really effective. The receptor status is determined through a biopsy, where a pathologist examines a sample of the tumor to check for the presence of these receptors. It is very important for determining the best course of action. The three main types, based on receptor status, are: